Memory and Amnesia

The goal of this team is to pinpoint the mechanisms behind human memory function, by implementing novel cognitive protocols and a range of brain imaging and electrophysiological techniques. It is particularly interested in the modifications that take place in (nondegenerative) pathologies and attaches a great deal of importance to developing new diagnostic and therapeutic strategies. Team 3’s research programme encompasses seven targeted studies. 1) The first of these is designed to improve current understanding of the neuropsychological and cerebral consequences of alcohol dependence and how these impact on patient care. 2) The second study will explore various aspects of memory, identity, and the ability to project oneself into the future, in patients in the acute phase of TGA and patients suffering either from functional amnesia or from a permanent amnesic syndrome. 3) In a study conducted in tandem with the French army medical services (SSA), the team will look into the isolated disturbances in memory consolidation caused by hypobaric hypoxia, about which little is currently known. 4) The fourth study will use fMRI investigations to try and understand how memory traces are reorganized during sleep, with a new procedure designed to boost slow waves via transcranial electrical stimulation, and to measure the impact of this manipulation on memory consolidation. 5) This study will examine the impact of cancers other than brain cancer on cognition, with a view to identifying the psychological and pathophysiological (fMRI scans) mechanisms behind memory disorders. 6) The aim of this clinical study of the functional neuroanatomy of PTSD will be to study the effects of stress on memory in adolescents. 7) The seventh and final study will measure the behavioural and electrophysiological effects of perceptual bias on memory in adolescents with autism.